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GABRB3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P28472
Clone Names 80109118
Additional Information
Gene ID 2562
Other Names Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, GABRB3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2789b was selected from the C-term region of human GABRB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABRB3
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity).
Cellular Location Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}
Research Areas
Citations (0)
citation

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Background

GABRB3 is a member of the ligand-gated ionic channel family. This protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism.

References

Vieira,A.R.,Am. J. Med. Genet. A 146A (21), 2828-2830 (2008)Russek,S.J., Genomics 23 (3), 528-533 (1994)Saitoh,S., Lancet 339 (8789), 366-367 (1992)

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$ 277.78
Cat# BP2789b
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