|Other Names||Glypican-4, K-glypican, Secreted glypican-4, GPC4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2790a was selected from the N-term region of human GPC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side|
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Provided below are standard protocols that you may find useful for product applications.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
Karumanchi,S.A., Mol. Cell 7 (4), 811-822 (2001)Hagihara,K., Dev. Dyn. 219 (3), 353-367 (2000)Veugelers,M., Hum. Mol. Genet. 9 (9), 1321-1328 (2000)Veugelers,M., Genomics 53 (1), 1-11 (1998)
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