|Other Names||Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.|
|Cellular Location||Lysosome membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a receptor formannose-6-phosphate groups on lysosomal enzymes. The receptor formsa homodimer or homotetramer for intracellular targeting oflysosomal enzymes and export of newly synthesized lysosomal enzymesinto the cell secretions. The receptor is an integral membraneprotein which localizes to the trans-Golgi reticulum, endosomes,and the plasma membrane.
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Op den Brouw, M.L., et al. Virology 393(1):84-90(2009)Schimanski, L.M., et al. Blood Cells Mol. Dis. 43(2):180-193(2009)Rodriguez-Gabin, A.G., et al. Exp. Cell Res. 315(13):2215-2230(2009)Xaplanteri, P., et al. Eur. J. Immunol. 39(3):730-740(2009)
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