|Other Names||Lipid phosphate phosphohydrolase 2, PAP2-gamma, PAP2-G, Phosphatidate phosphohydrolase type 2c, Phosphatidic acid phosphatase 2c, PAP-2c, PAP2c, PPAP2C, LPP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2799a was selected from the N-term region of human PPAP2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Found mainly in brain, pancreas and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
PPAP2C is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity.
Long,J.S., Biochem. J. 411 (2), 371-377 (2008)Morris,K.E., J. Biol. Chem. 281 (14), 9297-9306 (2006)Nanjundan,M., Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1), L1-L23 (2003)Zhang,N., Genesis 27 (4), 137-140 (2000)
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