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PSMD11 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00231
Clone Names 80612007
Peptide ID 80612007
Additional Information
Gene ID 5717
Other Names 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p445, PSMD11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2803b was selected from the C-term region of human PSMD11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMD11
Function Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Cellular Location Nucleus. Cytoplasm, cytosol
Tissue Location Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate
Research Areas
Citations (0)

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The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The protein is a non-ATPase subunit of the 19S regulator.


Saito,A., Gene 203 (2), 241-250 (1997)Hoffman,L., FEBS Lett. 404 (2-3), 179-184 (1997)

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$ 80.00
Cat# BP2803b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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