|Other Names||Nuclear autoantigenic sperm protein, NASP, NASP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2806b was selected from the C-term region of human NASP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity).|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Isoform 1 is testis- and sperm-specific.|
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Provided below are standard protocols that you may find useful for product applications.
NASP is a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.
Wang,H., Nucleic Acids Res. 36 (18), 5763-5772 (2008)Richardson,R.T., J. Biol. Chem. 281 (30), 21526-21534 (2006)
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