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WDYHV1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96HA8 |
|---|---|
| Clone Names | 80317132 |
| Gene ID | 55093 |
|---|---|
| Other Names | Protein N-terminal glutamine amidohydrolase, 351-, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, WDYHV motif-containing protein 1, WDYHV1, C8orf32, NTAQ1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2809c was selected from the Center region of human WDYHV1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NTAQ1 (HGNC:25490) |
|---|---|
| Synonyms | C8orf32, WDYHV1 |
| Function | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80WB5}. Nucleus {ECO:0000250|UniProtKB:Q80WB5} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lim,J., Cell 125 (4), 801-814 (2006)
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$ 277.78
Cat# BP2809c
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