|Other Names||Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP, DLGAP5, DLG7, KIAA0008|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2810a was selected from the N-term region of human DLG7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells|
|Tissue Location||Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta|
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DLG7 is a potential cell cycle regulator that may play a role in carcinogenesis of cancer cells and mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. The protein is also a key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
de Reynies,A., J. Clin. Oncol. 27 (7), 1108-1115 (2009)Gudmundsson,K.O., Stem Cells 25 (6), 1498-1506 (2007)Laprise,P., J. Biol. Chem. 279 (11), 10157-10166 (2004)
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