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RND1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92730 |
|---|---|
| Clone Names | 80612030 |
| Gene ID | 27289 |
|---|---|
| Other Names | Rho-related GTP-binding protein Rho6, Rho family GTPase 1, Rnd1, RND1, RHO6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2813a was selected from the N-term region of human RND1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RND1 |
|---|---|
| Synonyms | RHO6 |
| Function | Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton |
| Tissue Location | Mostly expressed in brain and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Rho GTPase family, such as RND1, regulate the organization of the actin cytoskeleton in response to extracellular growth factors.
References
Li,Y.H., J. Biol. Chem. 284 (1), 363-371 (2009)Tong,Y., J. Biol. Chem. 282 (51), 37215-37224 (2007)Harada,A., J. Biol. Chem. 280 (18), 18418-18424 (2005)
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