|Other Names||dCTP pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated gene A protein, DCTPP1, XTP3TPA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2821a was selected from the N-term region of human XTP3TPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Stelzl,U., Cell 122 (6), 957-968 (2005)Moroz,O.V., J. Mol. Biol. 347 (2), 243-255 (2005)
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