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SMPD2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60906 |
|---|---|
| Clone Names | 80612104 |
| Gene ID | 6610 |
|---|---|
| Other Names | Sphingomyelin phosphodiesterase 2, Lyso-platelet-activating factor-phospholipase C, Lyso-PAF-PLC, Neutral sphingomyelinase, N-SMase, nSMase, SMPD2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2822a was selected from the N-term region of human SMPD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SMPD2 (HGNC:11121) |
|---|---|
| Function | Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884). Also acts on 1-acyl-2-lyso-sn- glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:O70572}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
SMPD2 converts sphingomyelin to ceramide and hydrolyzes 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
References
Kim,H.T., J. Dermatol. Sci. 46 (2), 143-146 (2007)Tani,M., J. Biol. Chem. 282 (13), 10047-10056 (2007)Marchesini,N.,J. Biol. Chem. 279 (24), 25101-25111 (2004)
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