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IRF8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q02556
Clone Names 80522036
Peptide ID 80522036
Additional Information
Gene ID 3394
Other Names Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP, IRF8, ICSBP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2830b was selected from the C-term region of human IRF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF8
Synonyms ICSBP1
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).
Cellular Location Nucleus.
Tissue Location Predominantly expressed in lymphoid tissues.
Research Areas
Citations (0)

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Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.


McGough,J.M., Mol. Cancer Res. 6 (12), 1841-1851 (2008)Tshuikina,M., Exp. Hematol. 36 (12), 1673-1681 (2008)Martinez,A., Am. J. Surg. Pathol. 32 (8), 1190-1200 (2008)

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$ 80.00
Cat# BP2830b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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