LSM3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P62310 |
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Clone Names | 80522043 |
Gene ID | 27258 |
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Other Names | U6 snRNA-associated Sm-like protein LSm3, LSM3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2832a was selected from the N-term region of human LSM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LSM3 |
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Function | Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). |
Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
References
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)Ingelfinger,D., RNA 8 (12), 1489-1501 (2002)
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