|Other Names||U6 snRNA-associated Sm-like protein LSm5, LSM5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2833b was selected from the C-term region of human LSM5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro.|
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Provided below are standard protocols that you may find useful for product applications.
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)Ingelfinger,D., RNA 8 (12), 1489-1501 (2002)Eystathioy,T., Arthritis Rheum. 46 (3), 726-734 (2002)
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