SNRPC Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P09234 |
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Clone Names | 80612047 |
Gene ID | 6631 |
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Other Names | U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2841b was selected from the C-term region of human SNRPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
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Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774} |
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Provided below are standard protocols that you may find useful for product applications.
Background
SNRPC is associated with snRNP U1.
References
Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)Forch,P., EMBO J. 21 (24), 6882-6892 (2002)Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)
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