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SNRPC Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P09234
Clone Names 80612047
Additional Information
Gene ID 6631
Other Names U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2841b was selected from the C-term region of human SNRPC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Cellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774}
Research Areas
Citations (0)
citation

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Background

SNRPC is associated with snRNP U1.

References

Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)Forch,P., EMBO J. 21 (24), 6882-6892 (2002)Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)

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$ 277.78
Cat# BP2841b
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