|Other Names||Leukotriene A-4 hydrolase, LTA-4 hydrolase, Leukotriene A(4) hydrolase, LTA4H, LTA4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2844b was selected from the C-term region of human LTA4H. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.|
|Tissue Location||Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
DHCR24 hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity.
Bevan,S., Stroke 40 (3), 696-701 (2009)Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009)Huston,A.L., Biochim. Biophys. Acta 1784 (11), 1865-1872 (2008)Rybina,I.V., J. Biol. Chem. 272 (50), 31865-31871 (1997)
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