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MSH3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P20585
Clone Names 80522058
Peptide ID 80522058
Additional Information
Gene ID 4437
Other Names DNA mismatch repair protein Msh3, hMSH3, Divergent upstream protein, DUP, Mismatch repair protein 1, MRP1, MSH3, DUC1, DUG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2846c was selected from the Center region of human MSH3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSH3
Synonyms DUC1, DUG
Function Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Research Areas
Citations (0)

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Background

MSH3 is a component of the post-replicative DNA mismatch repair system (MMR). THis protein heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

References

Koessler,T., Int. J. Cancer 124 (8), 1887-1891 (2009)Haugen,A.C., Cancer Res. 68 (20), 8465-8472 (2008)Mann,A., Eur. J. Cancer 44 (15), 2259-2265 (2008)

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$ 80.00
Cat# BP2846c
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