|Other Names||Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, HSPH1, HSP105, HSP110, KIAA0201|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2860b was selected from the C-term region of human HSPH1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSP105, HSP110, KIAA0201|
|Function||Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).|
|Tissue Location||Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
HSPH1 prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. This protein inhibits HSPA8/HSC70 ATPase and chaperone activities.
Ishihara K., Yasuda K., Hatayama T.Biochim. Biophys. Acta 1444:138-142(1999)Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y.,DNA Res. 3:321-329(1996)The MGC Project Team Genome Res. 14:2121-2127(2004)Miyazaki M., Nakatsura T., Yokomine K., Senju S., Monji M., Hosaka S.,Cancer Sci. 96:695-705(2005)
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