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JTV1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13155
Clone Names 80317205
Additional Information
Gene ID 7965
Other Names Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1, AIMP2, JTV1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2861a was selected from the N-term region of human JTV1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIMP2
Synonyms JTV1
Function Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Cellular Location Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:Q8R010}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q8R010}
Research Areas
Citations (0)
citation

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Background

JTV1 is probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. This protein Mediates ubiquitination of FUBP1 and its degradation by the proteasome.

References

Nicolaides N.C., Kinzler K.W., Vogelstein B.Genomics 29:329-334(1995)Kim M.J., Park B.-J., Kang Y.-S., Kim H.J., Park J.-H., Kang J.W., Lee S.W., Nat. Genet. 34:330-336(2003)

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$ 277.78
Cat# BP2861a
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Availability: 2 weeks
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