|Other Names||Signaling lymphocytic activation molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2864a was selected from the Y307 region of human SLAMF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells|
|Tissue Location||Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation|
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Provided below are standard protocols that you may find useful for product applications.
SLAMF1 is high-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Mikhalap S.V., Shlapatska L.M., Berdova A.G., Law C.L.,J. Immunol. 162:5719-5727(1999)Tatsuo H., Ono N., Tanaka K., Yanagi Y.Nature 406:893-897(2000)Sayos J., Wu C., Morra M., Wang N., Zhang X., Allen D., van Schaik S.,Nature 395:462-469(1998)
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