|Other Names||Sister chromatid cohesion protein DCC1, Defective in sister chromatid cohesion protein 1 homolog, DSCC1, DCC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2874a was selected from the N-term region of human DCC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.|
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Provided below are standard protocols that you may find useful for product applications.
DCC1 is involved in sister chromatid cohesion establishment. The protein may act as a PCNA loader, loading PCNA onto primed templates.
Clark H.F., Gurney A.L.Genome Res. 13:2265-2270(2003) Merkle C.J., Karnitz L.M.J. Biol. Chem. 278:30051-30056(2003)
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