|Other Names||Sister chromatid cohesion protein DCC1, Defective in sister chromatid cohesion protein 1 homolog, DSCC1, DCC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.|
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Provided below are standard protocols that you may find useful for product applications.
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 arecomponents of an alternative replication factor C (RFC) (see MIM600404) complex that loads PCNA (MIM 176740) onto DNA during Sphase of the cell cycle (Merkle et al., 2003 [PubMed 12766176];Bermudez et al., 2003 [PubMed 12930902]).
Murakami, T., et al. J. Biol. Chem. 285(45):34608-34615(2010)Terret, M.E., et al. Nature 462(7270):231-234(2009)Watrin, E., et al. Curr. Biol. 16(9):863-874(2006)Bermudez, V.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(18):10237-10242(2003)Merkle, C.J., et al. J. Biol. Chem. 278(32):30051-30056(2003)
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