|Other Names||Sister chromatid cohesion protein DCC1, Defective in sister chromatid cohesion protein 1 homolog, DSCC1, DCC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 arecomponents of an alternative replication factor C (RFC) (see MIM600404) complex that loads PCNA (MIM 176740) onto DNA during Sphase of the cell cycle (Merkle et al., 2003 [PubMed 12766176];Bermudez et al., 2003 [PubMed 12930902]).
Murakami, T., et al. J. Biol. Chem. 285(45):34608-34615(2010)Terret, M.E., et al. Nature 462(7270):231-234(2009)Watrin, E., et al. Curr. Biol. 16(9):863-874(2006)Bermudez, V.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(18):10237-10242(2003)Merkle, C.J., et al. J. Biol. Chem. 278(32):30051-30056(2003)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.