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CD105 Antibody (Center E395) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P17813
Clone Names 81020004
Peptide ID 81020004
Additional Information
Gene ID 2022
Other Names Endoglin, CD105, ENG, END
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2880c was selected from the Center region of human CD105. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENG
Synonyms END
Function Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Endoglin is restricted to endothelial cells in all tissues except bone marrow
Research Areas
Citations (0)

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CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.


Chen,Y., Ann. Neurol. 66 (1), 19-27 (2009)Rius,C., Blood 92 (12), 4677-4690 (1998)

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$ 80.00
Cat# BP2880c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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