|Other Names||Adenine phosphoribosyltransferase, APRT, APRT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2893b was selected from the C-term region of human APRT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|
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Provided below are standard protocols that you may find useful for product applications.
A conserved feature of APRT is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis.
Silva,C.H., et. al.,J. Biomol. Struct. Dyn. 25 (6), 589-597 (2008)Di Pietro,V., et. al., Clin. Biochem. 40 (1-2), 73-80 (2007)
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