|Other Names||F-actin-capping protein subunit alpha-2, CapZ alpha-2, CAPZA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2895c was selected from the Center region of human CAPZA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|
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Provided below are standard protocols that you may find useful for product applications.
CAPZA2 is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end.
Denoeud,F., et.al.,Genome Res. 17 (6), 746-759 (2007)Miyagawa,Y., et.al., Mol. Hum. Reprod. 8 (6), 531-539 (2002)
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