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> home > Products > Peptides > Biological Process > Protein Modification Process > EIF5A Antibody (Center) Blocking Peptide
EIF5A Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP2901c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
EIF5A Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | P63241 |
| Clone Names | 81202034 |
| Calculated MW | 16832 Da |
EIF5A Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 1984 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP2901c was selected from the Center region of human EIF5A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
EIF5A Antibody (Center) Blocking Peptide - Protein Information | |
| Name EIF5A | |
| Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts | |
| Cellular Location Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions | |
| Tissue Location Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level) | |
EIF5A Antibody (Center) Blocking Peptide - Related products
AP2901b: EIF5A Antibody (C-term)
AP2901c: EIF5A Antibody (Center)
RI11741: EIF5A predesign siRNA
LY11663a: EIF5A Over-expression Lysate
BP2901b: EIF5A Antibody (C-term) Blocking Peptide
EIF5A Antibody (Center) Blocking Peptide - Research Areas
PeptidesBiological ProcessProtein Modification ProcessBiopolymer ModificationMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessRegulation Of Cell DeathRegulation Of Programmed Cell DeathRegulation Of ApoptosisPositive Regulation Of Cellular Metabolic ProcessPositive Regulation Of Metabolic ProcessPositive Regulation Of Macromolecule Metabolic ProcessPositive Regulation Of Biosynthetic ProcessPositive Regulation Of Cellular Biosynthetic ProcessMacromolecule Metabolic ProcessPositive Regulation Of Macromolecule Biosynthetic ProcessRegulation Of Cell ProliferationRegulation Of Protein Metabolic ProcessRegulation Of Cellular Protein Metabolic ProcessCellular Macromolecule Metabolic ProcessCellular Amino Acid And Derivative Metabolic ProcessPositive Regulation Of Cell Death
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EIF5A precursor is the only cellular protein known to contain a specific lysine residue which is transformed into the unique amino acid hypusine [N-(4-amino-2-hydroxybutyl)-lysine] by a series of post translational reactions. eIF5A promotes the formation of the first peptide bond during the initial stage of protein synthesis.
REFERENCES
Lee,S.B., et.al., Biochem. Biophys. Res. Commun. 383 (4), 497-502 (2009)Gosslau,A., et.al., J. Cell. Physiol. 219 (2), 485-493 (2009)
