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EEF2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P13639
Clone Names 81202029
Additional Information
Gene ID 1938
Other Names Elongation factor 2, EF-2, EEF2, EF2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2906a was selected from the N-term region of human EEF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EEF2
Synonyms EF2
Function Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl- tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721).
Cellular Location Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C- terminal cleavage product.
Research Areas
Citations (0)
citation

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Background

EEF2 is a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.

References

Redpath,N.T., et.al., Eur. J. Biochem. 213 (2), 689-699 (1993)Nakamura,J., et.al., Int. J. Oncol. 34 (5), 1181-1189 (2009)

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$ 277.78
Cat# BP2906a
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