PHGDH Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43175 |
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Clone Names | 81205092 |
Gene ID | 26227 |
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Other Names | D-3-phosphoglycerate dehydrogenase, 3-PGDH, PHGDH, PGDH3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2936a was selected from the N-term region of human PHGDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PHGDH |
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Synonyms | PGDH3 |
Function | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
3-Phosphoglycerate dehydrogenase catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
References
Klomp,L.W., et.al., Am. J. Hum. Genet. 67 (6), 1389-1399 (2000)
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