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PHGDH Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43175 |
|---|---|
| Other Accession | NP_006614 |
| Clone Names | 81205093 |
| Gene ID | 26227 |
|---|---|
| Other Names | D-3-phosphoglycerate dehydrogenase, 3-PGDH, PHGDH, PGDH3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PHGDH |
|---|---|
| Synonyms | PGDH3 |
| Function | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95)catalyzes the transition of 3-phosphoglycerate into3-phosphohydroxypyruvate, which is the first and rate-limiting stepin the phosphorylated pathway of serine biosynthesis, usingNAD+/NADH as a cofactor.
References
Du, H., et al. Reproduction 139(1):237-245(2010)Burton, R.L., et al. Biochemistry 48(22):4808-4815(2009)Kim, J.W., et al. Psychiatr. Genet. 19 (3), 161 (2009) :Tabatabaie, L., et al. Hum. Mutat. 30(5):749-756(2009)
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