|Other Names||Peroxiredoxin-5, mitochondrial, Alu corepressor 1, Antioxidant enzyme B166, AOEB166, Liver tissue 2D-page spot 71B, PLP, Peroxiredoxin V, Prx-V, Peroxisomal antioxidant enzyme, TPx type VI, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5, ACR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2937c was selected from the Center region of human PRDX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
PRDX5 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. This protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution.
Knoops,B., et.al., J. Biol. Chem. 274 (43), 30451-30458 (1999)Jurkunas,et.al., Invest. Ophthalmol. Vis. Sci. 49 (7), 2956-2963 (2008)
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