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Klotho Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UEF7
Clone Names 90415153
Peptide ID 90415153
Additional Information
Gene ID 9365
Other Names Klotho, Klotho peptide, KL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2945b was selected from the C-term region of human Klotho. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KL
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide Klotho peptide: Secreted.
Tissue Location Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney
Research Areas
Citations (0)

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Klotho is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.


Sugiyama,N.,, Mol. Cell Proteomics 6 (6), 1103-1109 (2007)

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$ 80.00
Cat# BP2945b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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