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CDT1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H211
Clone Names 80317144
Peptide ID 80317144
Additional Information
Gene ID 81620
Other Names DNA replication factor Cdt1, Double parked homolog, DUP, CDT1 {ECO:0000312|EMBL:AAG451811}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2952b was selected from the C-term region of human CDT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDT1 {ECO:0000312|EMBL:AAG45181.1}
Function Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Transiently localizes to kinetochores during prometaphase and metaphase
Research Areas
Citations (0)

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CDT1 Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It Binds DNA in a sequence-, strand-, and conformation-independent manner.


Whittaker,A.J.,, Genes Dev. 14 (14), 1765-1776 (2000)Nishitani,H.,, Nature 404 (6778), 625-628 (2000)Herbig,U.,, Mol. Biol. Cell 10 (8), 2631-2645 (1999)

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$ 80.00
Cat# BP2952b
Availability: In Stock
Bulk Size
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