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CDT1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H211 |
|---|---|
| Clone Names | 80317144 |
| Gene ID | 81620 |
|---|---|
| Other Names | DNA replication factor Cdt1, Double parked homolog, DUP, CDT1 {ECO:0000312|EMBL:AAG451811} |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2952b was selected from the C-term region of human CDT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDT1 {ECO:0000312|EMBL:AAG45181.1} |
|---|---|
| Function | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Transiently localizes to kinetochores during prometaphase and metaphase |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CDT1 Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It Binds DNA in a sequence-, strand-, and conformation-independent manner.
References
Whittaker,A.J., et.al., Genes Dev. 14 (14), 1765-1776 (2000)Nishitani,H., et.al., Nature 404 (6778), 625-628 (2000)Herbig,U., et.al., Mol. Biol. Cell 10 (8), 2631-2645 (1999)
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