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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Phospho-mouse Bid(S61) Antibody Blocking peptide   

Phospho-mouse Bid(S61) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P70444
Other Accession Q99M39
Clone Names 4103101
Peptide ID 4103101
Additional Information
Gene ID 12122
Other Names BH3-interacting domain death agonist, p22 BID, BID, BH3-interacting domain death agonist p15, p15 BID, BH3-interacting domain death agonist p13, p13 BID, BH3-interacting domain death agonist p11, p11 BID, Bid
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3040a was selected from the region of human Mouse Phospho-Bid-S61. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bid
Function Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.
Cellular Location Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane
Research Areas
Citations (0)

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Background

Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. Bid induces ICE-like proteases and apoptosis. It is amediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the major proteolytic product p15 Bid translocates to mitochondria where it triggers cytochrome c release.

References

J. Biol. Chem. 280 (46), 38271-38275 (2005)J. Biol. Chem. 280 (13), 12486-12493 (2005)J. Biol. Chem. 279 (28), 28954-28960 (2004)J. Biol. Chem. 279 (27), 28771-28780 (2004)J. Biol. Chem. 279 (4), 2846-2855 (2004)

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$ 80.00
Cat# BP3040a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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