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Phospho-mouse Bid(S61) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P70444
Other Accession Q99M39
Clone Names 4103101
Additional Information
Gene ID 12122
Other Names BH3-interacting domain death agonist, p22 BID, BID, BH3-interacting domain death agonist p15, p15 BID, BH3-interacting domain death agonist p13, p13 BID, BH3-interacting domain death agonist p11, p11 BID, Bid
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3040a was selected from the region of human Mouse Phospho-Bid-S61. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bid
Function Induces caspases and apoptosis. Counters the protective effect of BCL2.
Cellular Location Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P55957}. Note=When uncleaved, it is predominantly cytoplasmic. [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Note=Associated with the mitochondrial membrane.
Research Areas
Citations (0)
citation

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Background

Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. Bid induces ICE-like proteases and apoptosis. It is amediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the major proteolytic product p15 Bid translocates to mitochondria where it triggers cytochrome c release.

References

J. Biol. Chem. 280 (46), 38271-38275 (2005)J. Biol. Chem. 280 (13), 12486-12493 (2005)J. Biol. Chem. 279 (28), 28954-28960 (2004)J. Biol. Chem. 279 (27), 28771-28780 (2004)J. Biol. Chem. 279 (4), 2846-2855 (2004)

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$ 277.78
Cat# BP3040a
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Availability: 2 weeks
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