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Phospho-Cdk2-T160 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3067a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Phospho-Cdk2-T160 Antibody Blocking Peptide - Product info | |
| Primary Accession | P24941 |
| Clone Names | 4120756 |
| Calculated MW | 33930 Da |
Phospho-Cdk2-T160 Antibody Blocking Peptide - Additional info | |
| Gene ID 1017 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP3067a was selected from the region of human Phospho-Cdk2-T160. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-Cdk2-T160 Antibody Blocking Peptide - Protein Information | |
| Name CDK2 | |
| Synonyms CDKN2 | |
| Function Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT- mediated activation of histone gene transcription during S phase Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization | |
| Cellular Location Cytoplasm, cytoskeleton, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3) | |
Phospho-Cdk2-T160 Antibody Blocking Peptide - Related products
AP3067a: Phospho-Cdk2-T160 Antibody
AP3500a: Phospho-CDK2-pT41 Antibody
AP3613a: Phospho-CDK2-pT14 Antibody
AP7518b: CDK2 Antibody (C-term)
AP7518c: CDK2 Antibody (Center R199)
LY10013a: CDK2 Over-expression Lysate
BP3067a: Phospho-Cdk2-T160 Antibody Blocking Peptide
BP3500a: Phospho-CDK2-pT41 Antibody Blocking Peptide
BP3613a: Phospho-CDK2-pT14 Antibody Blocking Peptide
BP7518b: CDK2 Antibody (C-term) Blocking Peptide
BP7518c: CDK2 Antibody (Center R199) Blocking Peptide
BP7518d: CDK2 Antibody (T14) Blocking Peptide
AJ1177a: Cdk2 Antibody (C-term)
Phospho-Cdk2-T160 Antibody Blocking Peptide - Research Areas
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BACKGROUND
Cdk2 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
REFERENCES
Bicaku, E., et al., Tissue Cell 37(1):53-58 (2005).Lolli, G., et al., Structure (Camb.) 12(11):2067-2079 (2004).Ito, S., et al., Genes Cells 9(10):983-992 (2004).Zhou, M., et al., Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671 (2003).Kino, T., et al., Biochem. Biophys. Res. Commun. 298(1):17-23 (2002).
