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Phospho-CCNE1(T395) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P24864
Clone Names 4120753
Peptide ID 4120753
Additional Information
Gene ID 898
Other Names G1/S-specific cyclin-E1, CCNE1, CCNE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3081a was selected from the region of human Phospho-Cyclin E1-T395. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNE1
Synonyms CCNE
Function Essential for the control of the cell cycle at the G1/S (start) transition.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and placenta. Low levels in bronchial epithelial cells
Research Areas
Citations (0)

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Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E1 forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of Cyclin E1 has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.


Ausserlechner, M.J., et al., Leukemia 19(6):1051-1057 (2005).Wingate, H., et al., J. Biol. Chem. 280(15):15148-15157 (2005).Honda, R., et al., EMBO J. 24(3):452-463 (2005).Brzezinski, J., et al., Clin. Cancer Res. 11(3):1037-1043 (2005).Hayami, R., et al., Cancer Res. 65(1):6-10 (2005).

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$ 80.00
Cat# BP3081a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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