Phospho-mouse FADD(S191) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q61160 |
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Clone Names | 4100202 |
Gene ID | 14082 |
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Other Names | FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Protein FADD, Fadd, Mort1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3103a was selected from the region of human Mouse Phospho-FADD-S191. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Fadd {ECO:0000303|PubMed:8649383, ECO:0000312|MGI:MGI:109324} |
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Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
References
Zhang J., Winoto A. Mol. Cell. Biol. 16:2756-2763(1996).Hsu H., et al. Cell 84:299-308(1996).Jeong E.-J., et al. J. Biol. Chem. 274:16337-16342(1999).
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