|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3109b was selected from the region of human Phospho-Gab1-Y627. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).|
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Provided below are standard protocols that you may find useful for product applications.
Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).
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