|Other Names||Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3132a was selected from the region of human Phospho-IL3R-Y593. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
IL3R (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective IL3R has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.
Murphy, J.M., et al., J. Biol. Chem. 279(25):26500-26508 (2004).McClure, B.J., et al., Blood 101(4):1308-1315 (2003).Scibek, J.J., et al., Anal. Biochem. 307(2):258-265 (2002).Blake, T.J., et al., J. Leukoc. Biol. 72(6):1246-1255 (2002).Evans, C.A., et al., Blood 100(9):3164-3174 (2002).
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