|Other Names||Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3133a was selected from the region of human Phospho-IL3R-Y766. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IL3R (also known as CSF2RB) is a common beta chain of the high affinity receptor for IL-3, IL-5 and GM-CSF. Defective IL3R has been reported to be associated with protein alveolar proteinosis (PAP). PAP is an autosomal recessive fatal respiratory disease.
Murphy, J.M., et al., J. Biol. Chem. 279(25):26500-26508 (2004).McClure, B.J., et al., Blood 101(4):1308-1315 (2003).Scibek, J.J., et al., Anal. Biochem. 307(2):258-265 (2002).Blake, T.J., et al., J. Leukoc. Biol. 72(6):1246-1255 (2002).Evans, C.A., et al., Blood 100(9):3164-3174 (2002).
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