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Phospho-LPR1(S4520) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q07954
Clone Names 4103112
Additional Information
Gene ID 4035
Other Names Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3143a was selected from the region of human Phospho-LPR1-S452. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP1 (HGNC:6692)
Synonyms A2MR, APR
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).
Cellular Location [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Location Most abundant in liver, brain and lung.
Research Areas
Citations (0)
citation

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Background

LPR1 is involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.

References

Yu, G., et al., Blood 105(9):3545-3551 (2005).Cam, J.A., et al., J. Biol. Chem. 280(15):15464-15470 (2005).Niemeier, A., et al., J. Bone Miner. Res. 20(2):283-293 (2005).Spijkers, P.P., et al., Blood 105(1):170-177 (2005).Deane, R., et al., Neuron 43(3):333-344 (2004).

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$ 277.78
Cat# BP3143a
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