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Phospho-MECP2(S292) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51608
Clone Names 4051021
Additional Information
Gene ID 4204
Other Names Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3157a was selected from the 284-300 region of human Phospho-MECP2-pS292. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MECP2
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Cellular Location Nucleus. Note=Colocalized with methyl-CpG in the genome
Tissue Location Present in all adult somatic tissues tested.
Research Areas
Citations (0)

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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.


Mnatzakanian, G.N., et al., Nat. Genet. 36(4):339-341 (2004).Laccone, F., et al., Hum. Mutat. 23(3):234-244 (2004).Suzuki, M., et al., Oncogene 22(54):8688-8698 (2003).Balmer, D., et al., J. Mol. Med. 81(1):61-68 (2003).Hagberg, B., et al., Eur. J. Paediatr. Neurol. 7(6):417-421 (2003).

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$ 80.00
Cat# BP3157a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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