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Phospho-MEK3-S189 Antibody Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P46734
Clone Names 4022501
Additional Information
Gene ID 5606
Other Names Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3160a was selected from the 251-265 region of human Phospho-MEK3-S189. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP2K3
Synonyms MEK3, MKK3, PRKMK3, SKK2
Function Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Tissue Location Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues
Research Areas
Citations (0)

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Background

MEK3 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

References

Gensch, E., et al., J. Biol. Chem. 279(37):39085-39093 (2004).Woo, J.H., et al., Oncogene 23(10):1845-1853 (2004).Dirsch, V.M., et al., Oncogene 23(8):1586-1593 (2004).Ho, D.T., et al., J. Biol. Chem. 278(35):32662-32672 (2003).Sundarrajan, M., et al., Arthritis Rheum. 48(9):2450-2460 (2003).

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$ 120.00
Cat# BP3160a
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