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Phospho-p21Cip1(S130) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P38936
Clone Names 5022459
Peptide ID 5022459
Additional Information
Gene ID 1026
Other Names Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3187a was selected from the region of human Phospho-p21Cip1-pS130. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA
Function May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in all adult tissues, with 5-fold lower levels observed in the brain
Research Areas
Citations (0)

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p21 is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this protein is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. p21 can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. It was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.


Scott, S.A., et al., Leuk. Res. 28(12):1293-1301 (2004).Amini, S., et al., J. Biol. Chem. 279(44):46046-46056 (2004).Chen, T., et al., Cancer Res. 64(20):7412-7419 (2004).Sieburg, M., et al., J. Virol. 78(19):10399-10409 (2004).Giraud, S., et al., Oncogene 23(44):7391-7398 (2004).

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$ 80.00
Cat# BP3187a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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