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Phospho-p27Kip1-T187 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3194a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Phospho-p27Kip1-T187 Antibody Blocking Peptide - Product info | |
| Primary Accession | P46527 |
| Clone Names | 4120752 |
| Calculated MW | 22073 Da |
Phospho-p27Kip1-T187 Antibody Blocking Peptide - Additional info | |
| Gene ID 1027 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP3194a was selected from the region of human Phospho-p27Kip1-T187. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-p27Kip1-T187 Antibody Blocking Peptide - Protein Information | |
| Name CDKN1B | |
| Synonyms KIP1 | |
| Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | |
| Cellular Location Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity) | |
| Tissue Location Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney | |
Phospho-p27Kip1-T187 Antibody Blocking Peptide - Related products
AP10418a: 27Kip1-T157 Antibody
AP13302b: CDKN1B Antibody (C-term)
AP3191a: Phospho-p27Kip1-S10 Antibody
AP3192a: Phospho-p27Kip1-S178 Antibody
AP3193a: Phospho-p27Kip1-T157 Antibody
AP3194a: Phospho-p27Kip1-T187 Antibody
AP3529a: Phospho-p27Kip1-T198 Antibody
AP6269b: 27Kip1 Antibody (C-term)
RI10983: CDKN1B predesign siRNA
LY12364a: CDKN1B Over-expression Lysate
BP10418a: 27Kip1-T157 Antibody Blocking peptide
BP3191a: Phospho-p27Kip1-S10 Antibody Blocking Peptide
BP3192a: Phospho-p27Kip1-S178 Antibody Blocking Peptide
BP3193a: Phospho-p27Kip1-T157 Antibody Blocking Peptide
BP3194a: Phospho-p27Kip1-T187 Antibody Blocking Peptide
BP3529a: Phospho-p27Kip1-T198 Antibody Blocking Peptide
BP6269b: 27Kip1 Antibody (C-term) Blocking Peptide
AT1481a: CDKN1B Antibody (monoclonal) (M01)
AJ1569c: p27/Kip1 Antibody (C-term)
AJ1569d: p27/Kip1 Antibody Phospho (pS10)
Phospho-p27Kip1-T187 Antibody Blocking Peptide - Research Areas
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BACKGROUND
p27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
REFERENCES
Kawamata, N., et al., Eur. J. Haematol. 74(5):424-429 (2005).Andreu, E.J., et al., Cancer Res. 65(8):3264-3272 (2005).Wingate, H., et al., J. Biol. Chem. 280(15):15148-15157 (2005).Wang, C., et al., J. Biol. Chem. 280(13):12339-12343 (2005).Rassidakis, G.Z., et al., Blood 105(2):827-829 (2005).
