|Other Names||Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, PTPRA, PTPA, PTPRL2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3221a was selected from the region of human Phospho-PTPa-S180. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PTPa is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation.
Kapp, K., et al., Biochem. Biophys. Res. Commun. 311(2):361-364 (2003).Zhang, X.Q., et al., Oncogene 22(43):6704-6716 (2003).Yahiro, K., et al., J. Biol. Chem. 278(21):19183-19189 (2003).Pettiford, S.M., et al., Leukemia 17(2):366-378 (2003).van der Wijk, T., et al., J. Biol. Chem. 278(16):13968-13974 (2003).
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