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Phospho-PTPa(S204) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18433 |
|---|---|
| Clone Names | 2121102 |
| Gene ID | 5786 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, PTPRA, PTPA, PTPRL2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3222a was selected from the region of human Phospho-PTPa-S204. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTPRA |
|---|---|
| Synonyms | PTPA, PTPRL2 |
| Function | Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPa is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation.
References
Kapp, K., et al., Biochem. Biophys. Res. Commun. 311(2):361-364 (2003). Zhang, X.Q., et al., Oncogene 22(43):6704-6716 (2003). Yahiro, K., et al., J. Biol. Chem. 278(21):19183-19189 (2003). Pettiford, S.M., et al., Leukemia 17(2):366-378 (2003). van der Wijk, T., et al., J. Biol. Chem. 278(16):13968-13974 (2003).
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