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Phospho-SEPARIN-S1501Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14674
Clone Names 5021462
Additional Information
Gene ID 9700
Other Names Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3245a was selected from the 1494-1508 region of human Phospho-SEPARIN-S1501. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESPL1
Synonyms ESP1, KIAA0165
Function Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.


Chestukhin, A., et al., Proc. Natl. Acad. Sci. U.S.A. 100(8):4574-4579 (2003).Waizenegger, I., et al., Curr. Biol. 12(16):1368-1378 (2002).Chen, F., et al., J. Biol. Chem. 277(19):16775-16781 (2002).Hauf, S., et al., Science 293(5533):1320-1323 (2001).Zou, H., et al., Science 285(5426):418-422 (1999).

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$ 80.00
Cat# BP3245a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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