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Phospho-SEPARIN(S1126) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q14674
Clone Names 5021460
Peptide ID 5021460
Additional Information
Gene ID 9700
Other Names Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3247a was selected from the 1119-1133 region of human Phospho-SEPARIN-S1126. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESPL1
Synonyms ESP1, KIAA0165
Function Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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The metaphase-to-anaphase transition is the final discrete event in duplication and separation of the genetic material of the cell. Its timing is regulated by the activation of the anaphase-promoting complex (APC). In both budding and fission yeast, the degradation of the Pds1 or Cut2 protein, respectively, is required for the onset of sister chromatid separation. Both proteins are APC substrates. Pds1 and Cut2 proteins associate with the yeast separin proteins Esp1 and Cut1, respectively, and prevent the separins from promoting chromatid separation. Pds1 and Cut2 are also called anaphase inhibitors or securins


Chestukhin, A., et al., Proc. Natl. Acad. Sci. U.S.A. 100(8):4574-4579 (2003).Waizenegger, I., et al., Curr. Biol. 12(16):1368-1378 (2002).Chen, F., et al., J. Biol. Chem. 277(19):16775-16781 (2002).Hauf, S., et al., Science 293(5533):1320-1323 (2001).Zou, H., et al., Science 285(5426):418-422 (1999).

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$ 120.00
Cat# BP3247a
Availability: In Stock
Bulk Size
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