|Other Names||Signal transducer and activator of transcription 4, STAT4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3264a was selected from the region of human Phospho-STAT4-Y693. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation|
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Provided below are standard protocols that you may find useful for product applications.
STAT4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT4 is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Torpey, N., et al., J. Biol. Chem. 279(25):26789-26796 (2004).Arora, T., et al., J. Biol. Chem. 278(24):21327-21330 (2003).Monteleone, G., et al., J. Immunol. 170(1):300-307 (2003).Lovato, P., et al., J. Biol. Chem. 278(19):16777-16781 (2003).Nakahira, M., et al., J. Immunol. 168(3):1146-1153 (2002).
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