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Phospho-STAT5a(Y694) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P42229
Clone Names 4020211
Peptide ID 4020211
Additional Information
Gene ID 6776
Other Names Signal transducer and activator of transcription 5A, STAT5A, STAT5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3268a was selected from the region of human Phospho-STAT5a-Y694. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms STAT5
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
Research Areas
Citations (0)

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STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.


Martens, N., et al., J. Biol. Chem. 280(14):13817-13823 (2005).Defilippi, P., et al., J. Cell Biol. 168(7):1099-1108 (2005).Sekine, Y., et al., J. Biol. Chem. 280(9):8188-8196 (2005).Sultan, A.S., et al., Oncogene 24(5):746-760 (2005).Moriggl, R., et al., Cancer Cell 7(1):87-99 (2005).

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$ 80.00
Cat# BP3268a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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